Very little is known about Sarek's childhood or the early years of his life. He was born in 2165 to Skon and T'Rama, but no information is available about his parents.
Sarek was bonded to T'Rei, who was a Vulcan priestess. She gave birth to Sarek's first son Sybok. Sarek, however, did not know of Sybok's existence till after T'Rei's death, some years later.
Sarek, taught and did research into computer technology at the Vulcan Academy of Science for 8.6 years when the Vulcan matriarch T'Pau (also related to Sarek) dispatched Sarek with the Embassy to Earth. For the first 10 years on Earth Sarek was a technical attaché, then he was promoted to cultural attaché, and after another 15 years he was elevated to the diplomatic corps.
In the summer of 2212 he returned to Vulcan, only to find that he was to be
the successor of the retiring Vulcan ambassador, Sasav.
During his stay on Earth, his first wife T'Rei had
died. He returned to Earth as ambassador, and shortly after met Amanda Greyson, a teacher/translator of languages, with special
interest in Vulcan. (There are a number of accounts of how the two met and
eventually bonded. When asked, neither Sarek
or Amanda are (were) forthcoming. So if you want to explore these
various stories refer to a)Spock's World by
Diane Duane. b)
Amanda became Sarek's wife and after a couple of years they moved to Vulcan, where their son, Spock was conceived/designed and born in 2230.
Sarek continued to divide his time between teaching at the Academy and working as an Ambassador of Vulcan.
Amanda also taught, and led a long life after being successfully treated for Degenerative Xenosis (See reference "b" above). She died in 2293 of Reyerson's disease at the age of 93 (reference "c").
Much later, Sarek remarried to another human, Perrin. He had no children with her, as far as is known. Sarek died/dies* in 2366, at the age of 202, from Bendii Syndrome (TNG:Sarek).
* "The distinction between past, present and future is only a stubbornly persistent illusion." Albert Einstein